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A plastic model of a heart, illustrating research into modeling heart diseases.
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Maturation of Heart Organoids Enables Complex Disease Modeling

Researchers have mimicked the effects of exercise on heart organoids, maturing the cells to make them behave more like adult heart tissue.
Blue and read drug capsule split in half with silver molecules coming out.
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Scientists Target Brain Cancer With Innovative Myosin Motor Drug

A potential treatment for glioblastoma crafted by scientists at The Wertheim UF Scripps Institute renders the deadly brain cancer newly sensitive to both radiation and chemotherapy drugs, and blocks the cancer’s ability to invade other tissues.
3D rendering of fat cells with visible nuclei and membranes in a blue-tinted environment.
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Fat Cells Genetically Altered To Extend Lifespan and Improve Health

A study reveals that genetically altering fat cells in mice to overproduce the hormone FGF21 leads to improved metabolic health, including better blood sugar control and cholesterol levels.
Cells with fluid interiors, illustrating cellular processes.
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Boosting Cells' Lysosomes Promotes Healthy Aging

Researchers have discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cells' lysosomes can help clear waste and promote healthy aging.
T cells with surface proteins visible, illustrating the signaling that shapes the structure of the thymus.
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T-Cell Feedback Shapes Complex Structure of the Thymus

Thymic crosstalk between T cells and the thymus during T-cell priming shapes how the thymus grows and shapes itself.
Cells with fluid interiors, illustrating cell state control and senescence.
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Researchers Induce Senesence in Worms

Researchers have induced a senescent-like state in worms, providing a model to explore how senescence can be triggered and overcome.
Digital visualization of DNA base pairs representing genetic sequencing data.
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New Approach Combines Imaging and Sequencing for Gene Function

The Perturb-Multi method combines imaging and sequencing to study gene function in intact tissue. By analyzing liver tissue from genetically modified mice, the team discovered new mechanisms involved in liver fat accumulation.
Illustration of purple iridescent T cells.
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BiTS Antibody Silences T Cells Driving Autoimmune Disease

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type 1 diabetes, hepatitis and multiple sclerosis, shows a new study in mice.
Younger and older adult holding hands.
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Inflammation Tied to Lifestyle, Not Just Aging

Inflammation, long considered a hallmark of aging, may not be a universal human experience, according to a new study from Columbia University Mailman School of Public Health.
This triple-negative breast cancer organoid was grown in the lab using tissue samples donated by a volunteer patient. LINC01235 is seen in red.
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The Hidden Role of LINC01235 in Triple-Negative Breast Cancer

A new discovery could help point toward the first effective therapy being discovered for triple-negative breast cancer.
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