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The ZenoTOF 8600: The Proof Is In The Data
Credit: Sciex
To drive new discoveries and prove biological significance, you need technology that can outperform what you currently have. You need technology that unlocks new approaches that weren’t possible before. You need quantitative data of the highest quality; data you can stake your reputation on.
The SCIEX ZenoTOF 8600 system combines proven technology from our most sensitive triple quad with our most versatile Zeno trap-enabled QTOF. Delivering 10x better sensitivity than the current SCIEX accurate mass system across many new and established accurate mass approaches. This translates not only into the lower limits of quantitation but also into new enabled approaches to making biologically relevant discoveries that data can prove.
In the quest to make groundbreaking biological discoveries, the quality of data and the technology used are paramount. The ZenoTOF 8600 system represents a leap forward in mass spectrometry, offering noteworthy sensitivity and precision. You’re understandably skeptical. You’re supposed to be. That’s why we’re giving you access to the technical data driving our claims as a part of our launch, so you can see for yourself.
Sensitivity Zeno MS/MS (positive ESI)Reserpine 50 fg on column using the fragment m/z 195.0651,with a 10 mDa MEW S/N > 8000
Sensitivity Zeno MS/MS (negative ESI)Chloramphenicol 100 fg on column using the fragment m/z 152.0350,with a 10 mDa MEW S/N > 15000
MS/MS duty cycleWhen activated, the Zeno trap allows ≥90% duty cycle for TOF MS/MS acquisition
Fragmentation modesCollision induced dissociation (CID) and electron activated dissociation (EAD)
Mass resolution, positive ESI≥ 45,000 (FWHM) measured on the [M+6H]6+ chargeisotope cluster for bovine insulin at m/z 956
Mass accuracy MS/MS, internal≤0.2 ppm absolute error as demonstrated on m/z 813 fragment ionof Glu-Fibrinopeptide B, internally calibrated ≤0.5 ppm absolute error as demonstrated on m/z 120 fragment ion of Glu-Fibrinopeptide B, internally calibrated
Mass rangeTOF: up to 40 kDa, Precursor ion selection: m/z 5-2250
Detector typeA long-life, wide dynamic range optical-based pulse counting, 4-channel detector, utilizing ADC signal capture technology
Intra-scan dynamic rangeIn both TOF MS and Zeno MS/MS; ≥ 5 orders of magnitude linear dynamic range without signal reduction for Atorvastatin
Linear dynamic range negativeIn both TOF MS and Zeno MS/MS; ≥ 5 orders of magnitude linear dynamic range without signal reduction for Chloramphenicol
About SCIEX
SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research.
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