TwoMP Auto - Accelerate Lead Discovery and Development with Automated Mass Photometry

Name: TwoMP Auto - Accelerate Lead Discovery and Development with Automated Mass Photometry
Brand: Refeyn

Credit: Refeyn

Automated mass photometry combines the ease and efficiency of automation with the unmatched sensitivity and simplicity of Refeyn’s molecular mass measurement technology. The TwoMP Auto mass photometer automatically measures up to 24 samples in as little as 90 minutes, freeing up operator time, and offers enhanced precision, enabling rapid measurement with low sample consumption. Automation is compatible with the TwoMP.

- Rapid, automated measurement of multiple samples
- Ideal for screening and titration assays
- Highly reproducible data with user-friendly software
- Compatible with TwoMP unit

Product Specifications

Mass range: 30 kDa – 5 Mda

Resolution (FWHM): 25 kDa @ 66 kDa / 60 kDa @ 660 kDa

Mass precision: ± 2%

Single measurement mass accuracy: ± 5%

Concentration range: 1 nM – 100 nM

Sample volume: 5 μL

Min. well plate volume: 30 µL for V-bottom well plate (only available on newer or upgraded systems), 50 µL for flat-bottom well plate

Time to result: ≈90 minutes for 24 samples

Wavelength: 488 nm

Field of view: 4 x 11 µm (@ 500 Hz) up to 12 x 17 µm (@ 135 Hz)

Derisk Early and Accelerate Antibody Development With Mass Photometry

Stephen Maughan uses real-world data and case studies to demonstrate how mass photometry streamlines development projects involving mAbs, BsAbs, and ADCs – and how it compares to SEC

Banner for the 8th Annual Bioprocessing Summit Europe, March 18–20, 2025, in Barcelona, Spain and virtual (CET)

Video

Derisk Early and Accelerate Antibody Development With Mass Photometry

Cover of a Refeyn technical note on antibody aggregation analysis using mass photometry as a column-free method orthogonal to SEC-UV, featuring blue antibody structures on a dark background

App Note / Case Study

Mass Photometry, a Column-Free Orthogonal to SEC-UV

In this technical note, we explore datasets captured through mass photometry and size exclusion chromatography (SEC), comparing how they characterize the aggregation levels in different biosimilar antibodies

App Note / Case Study

Mass Photometry, a Column-Free Orthogonal to SEC-UV

Refeyn application note on forced antibody degradation using automated mass photometry, featuring sample data graph and descriptive text

App Note / Case Study

Mass Photometry in a Forced Antibody Degradation Study

In this application note, discover how mass photometry can be used to analyze the fragmentation and aggregation of therapeutic antibodies in response to stressors like light, pH variations, and peroxide exposure.

App Note / Case Study

Mass Photometry in a Forced Antibody Degradation Study

About Refeyn

Refeyn pioneers analytical instruments that put molecular mass measurement capabilities within easy reach for scientists. Refeyn’s unique products measure the mass of individual proteins, nucleic acids, complexes and viruses directly in solution – providing vital insights for scientific discovery, research and development and therapeutics production.

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