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Latest App Notes & Case Studies

High-throughput screening of the compound collection across europe
App Note / Case Study

Why Automation is Integral to the EU-OPENSCREEN Compound Collection

This case study highlights how EU-OPENSCREEN implemented a fully automated workflow for compound dissolution, aliquoting, storage and plate reformatting, meeting the scale and speed of modern screening demands.
Front cover of a Cytiva and Nuclera application note on accelerated kinase drug discovery workflow.
App Note / Case Study

Accelerated Kinase Drug Discovery: From DNA to Protein Characterization in 5 Days

This application note presents a next-generation approach to drug discovery - combining AI-guided structural design with rapid, automated digital microfluidics-based screening workflows that optimize protein expression. Researchers can obtain purifi
Close-up of dried blood spots on filter paper within printed collection circles for analysis.
App Note / Case Study

Trace-Level Detection of Nitazenes in Dried Blood Spot Samples

This application note highlights a complete extraction-to-analysis method that offers the exceptional sensitivity and robust quantitation needed to analyze nine nitazene analogs and brorphine in DBS samples.
Doctor holding a glowing capsule symbolizing AI-driven drug discovery and molecular innovation
App Note / Case Study

AI-Driven Therapeutic Antibody Design

This application note explores how researchers successfully combined AI with advanced multiplexed gene synthesis to design and validate novel single-domain antibodies with atomic-level precision.
Refeyn application note on forced antibody degradation using automated mass photometry, featuring sample data graph and descriptive text
App Note / Case Study

Mass Photometry in a Forced Antibody Degradation Study

In this application note, discover how mass photometry can be used to analyze the fragmentation and aggregation of therapeutic antibodies in response to stressors like light, pH variations, and peroxide exposure.
Cover of a Refeyn technical note on antibody aggregation analysis using mass photometry as a column-free method orthogonal to SEC-UV, featuring blue antibody structures on a dark background
App Note / Case Study

Mass Photometry, a Column-Free Orthogonal to SEC-UV

In this technical note, we explore datasets captured through mass photometry and size exclusion chromatography (SEC), comparing how they characterize the aggregation levels in different biosimilar antibodies
3D rendering of multiple antibody molecules, shown as blue and purple Y-shaped structures floating in a dark background.
App Note / Case Study

Analyze Purity and Charge Heterogeneity on a Single Platform

This app note explores a how single multi-capillary, high-throughput platform can be used to perform both these techniques, enabling complex biotherapeutics to be rapidly and thoroughly characterized.
Brochure on E. coli fermentation scale-up from 200L stainless steel to 1000L single-use fermenter
App Note / Case Study

Successful Scale-Up for High-Density Microbial Processes

This application note highlights the successful 5-fold scale-up of a high-cell density E. coli process from an established 200 L stainless steel fermenter to a 1000 L single-use system.
Close up of a womens hand in a glove with a test tube.
App Note / Case Study

Optimizing Metabolite Identification With Electron-Activated Dissociation

This app note highlights the advantages of electron-activated dissociation (EAD) in identifying oxidative metabolites of the molecular glue, mezigdomide.
Women using a asthma inhaler
App Note / Case Study

Ultra-Sensitive Quantification of Fluticasone Propionate

This application note highlights a LC-MS/MS method that leverages advanced sample preparation and next-generation detection technology to achieve high sensitivity and accuracy while minimizing sample volume requirements.
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