Latest App Notes & Case Studies

App Note / Case Study
Why Automation is Integral to the EU-OPENSCREEN Compound Collection
This case study highlights how EU-OPENSCREEN implemented a fully automated workflow for compound dissolution, aliquoting, storage and plate reformatting, meeting the scale and speed of modern screening demands.

App Note / Case Study
Accelerated Kinase Drug Discovery: From DNA to Protein Characterization in 5 Days
This application note presents a next-generation approach to drug discovery - combining AI-guided structural design with rapid, automated digital microfluidics-based screening workflows that optimize protein expression. Researchers can obtain purifi

App Note / Case Study
Trace-Level Detection of Nitazenes in Dried Blood Spot Samples
This application note highlights a complete extraction-to-analysis method that offers the exceptional sensitivity and robust quantitation needed to analyze nine nitazene analogs and brorphine in DBS samples.

App Note / Case Study
AI-Driven Therapeutic Antibody Design
This application note explores how researchers successfully combined AI with advanced multiplexed gene synthesis to design and validate novel single-domain antibodies with atomic-level precision.

App Note / Case Study
Mass Photometry in a Forced Antibody Degradation Study
In this application note, discover how mass photometry can be used to analyze the fragmentation and aggregation of therapeutic antibodies in response to stressors like light, pH variations, and peroxide exposure.

App Note / Case Study
Mass Photometry, a Column-Free Orthogonal to SEC-UV
In this technical note, we explore datasets captured through mass photometry and size exclusion chromatography (SEC), comparing how they characterize the aggregation levels in different biosimilar antibodies

App Note / Case Study
Analyze Purity and Charge Heterogeneity on a Single Platform
This app note explores a how single multi-capillary, high-throughput platform can be used to perform both these techniques, enabling complex biotherapeutics to be rapidly and thoroughly characterized.

App Note / Case Study
Successful Scale-Up for High-Density Microbial Processes
This application note highlights the successful 5-fold scale-up of a high-cell density E. coli process from an established 200 L stainless steel fermenter to a 1000 L single-use system.

App Note / Case Study
Optimizing Metabolite Identification With Electron-Activated Dissociation
This app note highlights the advantages of electron-activated dissociation (EAD) in identifying oxidative metabolites of the molecular glue, mezigdomide.

App Note / Case Study
Ultra-Sensitive Quantification of Fluticasone Propionate
This application note highlights a LC-MS/MS method that leverages advanced sample preparation and next-generation detection technology to achieve high sensitivity and accuracy while minimizing sample volume requirements.
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