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Adult Stem Cells Isolated From a Non-Human Primate for the First Time
For the first time, researchers have discovered and isolated adult stem cells from a non-human primate. This finding could transform the foundation for how we develop stem cell treatments.

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Antibody Targets Immune Receptor Pairing To Regulate T Cell Response
Study identifies proximity-based mechanism behind LAG-3 inhibition and introduces novel bispecific antibody for autoimmune intervention.

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Mouse Model for Ultra-Rare Neurological Disorder Could Pave the Way for Gene Editing Therapies
Scientists have developed mouse models that survive premature death and enable preclinical testing of alternating hemiplegia of childhood, or AHC, a devastating and sometimes fatal neurological disorder that affects about one in a million children.

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OTOF Gene Therapy Successfully Improves Hearing in Clinical Trial
Researchers tested a gene therapy that restored partial hearing in patients with OTOF gene mutations causing congenital deafness. The therapy delivered a functional OTOF gene using an adeno-associated virus (AAV) injection.

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“Leukemia-on-a-Chip” Offers a New Tool for Screening CAR T-Cell Therapy
Researchers have pioneered a novel 3D platform that mimics the human bone marrow and immune environment, enabling more predictive testing of cancer immunotherapy success in patients, including CAR T cell therapies.

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Flu Vaccine Adjuvant Improves Cross Protection Against Influenza Viruses
Influenza hemagglutinin subunit vaccines are more effective and offer better cross protection against various influenza virus challenges when combined with a mucosal adjuvant, according to a study.

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New Approach Combines Imaging and Sequencing for Gene Function
The Perturb-Multi method combines imaging and sequencing to study gene function in intact tissue. By analyzing liver tissue from genetically modified mice, the team discovered new mechanisms involved in liver fat accumulation.

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Slowing Down the Intracellular Transport of RNA-Based Drugs Improves Efficacy
A recent study reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These therapeutics are currently used to treat rare genetic diseases.

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Machine Learning Algorithm Predicts Protein-Water Contributions to Drug Binding
Water molecules represent a powerful but largely underappreciated foothold in drug binding studies. See how ColdBrew can provide accurate water displacement predictions for protein structures, providing a clearer landscape for drug discovery.

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Gene Therapy Normalizes Blood Flow in the Brain
Findings from three patients in a gene therapy clinical trial showed that gene therapy treatment significantly improved blood flow in the brain. These results demonstrate that people with associated risk factors should be considered for trials.
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